Relationship Between Mean Vancomycin Trough Concentration and Mortality in Critically Ill Patients: A Multicenter Retrospective Study

Background: It remains unclear whether the mean vancomycin trough concentration (VTC) derived from entire course of therapy is potential benefit for critically ill patients. This study was conducted to explore association between serum VTC and mortality in intensive care units (ICUs). Methods: 3,603 adult patients with two or more records after receiving treatment eICU Collaborative Research Database were included this multicenter retrospective cohort study. Mean estimated using all measured VTCs investigated as a continuous categorical variable. Patients categorised into four groups according VTC: <10, 10–15, 15–20, >20 mg/L. Multivariable logistic regression subgroup analyses performed investigate relationship mortality. Results: After adjusting series covariates, indicated that VTC, variable, positively correlated ICU (odds ratio, 1.038, 95% confidence interval, [1.014–1.063]) hospital (1.025 [1.005–1.046]) mortalities. As 10–15 mg/L not associated reduced (1.705 [0.975–2.981]) (1.235 [0.829–1.841]) 15–20 lower risk (1.370 [0.924–2.029]). Moreover, significantly higher (1.924 [1.111–3.332]; 2.428 [1.385–4.258]), (1.585 [1.053–2.387]) than <10 Similar results observed different Acute Physiology Chronic Health Evaluation IV score, creatinine clearance, age, body mass index subgroups. Conclusion: ICU/hospital related Our suggested monitoring might guarantee efficacy